MyFatDog        

January 2011

Esperion Therapeutics announces initiation of a phase II study with ETC-1002, a drug being tested to lower LDL  (ClinicalTrials.gov link to study)

Trial with polypill containing simvastatin plus three blood pressure medications to begin in the UK

Birch tree bark extract found to lower cholesterol

December 2010

Quitting smoking improves good cholesterol

Abbott and AstraZeneca discontinue the combination pill Certriad (Crestor + TriLipix)

Brief overview of the effect of betaine on cholesterol levels

Oxysterols, made in the body from cholesterol, are associated with several diseases

November 2010

Amarin reports AMR101 safely and effectively lowers triglycerides with no effect on LDL levels.

Vytorin (ezetimibe/simvastatin) reduces cardiovascular events in patients with kidney disease.

Statins have cardiovascular benefit in patients with non-alcoholic fatty liver disease.

Pine oil byproducts provide a source of neutraceutical plant sterols

Publicity about low cholesterol in goat meat prompts a spike in goat thefts

Canada officially recognizes benefit of oat fiber in reducing cholesterol

NicOx reports results from phase Ib study with NCX-6560.  LDL lowering similar to atorvastatin.

 Results from the ASSERT trial with RVX-208.  Study fails to meet primary endpoint of increasing apoA-I.

 Results from the DEFINE trial with anacetrapib (MK-0859).  Drug lowers LDL by and additional 40% in patients treated with a statin. 

October 2010 

Karo Bio raises US$45 million to conduct phase III studies with eprotirome 

AtheroNova reports lead compound reduces arterial plaque by 95% in a preclinical study

August 2010

Mipomersen successfully lowers LDL in high risk and statin-resistant patients: treatment associated with a high rate of drug discontinuation during study

Cholesterol drugs don't help the healthy

July 2010

Karo Bio to target patients with heterozygous familial hypercholesterolemia for treatment with their thyroid receptor beta activator eprotirome

June 2010

Three new studies question the benefit of statin treatment in people with normal cholesterol levels

Genfit announces development plans for GFT505

Anthera begins recruitment in the VISTA-16 trial, a 16 week trial with varespladib in patients with acute coronary syndrome

Spherix to explore the use ofD-tagatose as a therapy for treatment of high triglyceride levels

People with bipolar disorder twice as likely to have metabolic syndrome (high blood pressure, increased waist circumference, high glucose,high triglycerides and low HDL).

Esperion collaborating with the Cleveland Clinic on new cholesterol treatments

Short people twice as likely to develop heart disease as taller people

New paper shows trend of HDL delipidation treatment towards atherosclerosis regression

New paper shows that RVX-208 increases HDL levels in monkeys but not in man. 

The hormone ghrelin regulates LDL levels through the brain

Iron levels in liver associated with cholesterol synthesis and fatty liver

Processed meat consumption asssociated with risk of heart disease